The Charles T. Campbell Eye Microbiology Lab
UPMC | University of Pittsburgh Medical CenterUniversity of Pittsburgh Schools of the Health Sciences
HomeAbout UsLab Diagnostic TestingAntibiotic SusceptibilityAntimicrobial TherapyCurrent ResearchContact Us

2001 Ocular Microbiology and Immunology Group, Abstract 16

OMIG Main Page | 2001 Abstracts| < Previous | Next>

Vancomycin Kill Curves for Ocular Isolates
R.W. Snyder1. T. Krueger2 and D.E. Nix2
1Departments of Ophthalmology and 2Pharmacy Practice & Science, University of Arizona, Tucson, AZ

Purpose: Intracameral vancomycin has been advocated to prevent post-cataract surgery endophthalmitis. To be effective it must be broad spectrum, non-toxic, and fast acting. In this study we determined the kill curves against ocular isolates.

Methods: The MICs were determined for 15 coagulase-negative Staphylococcus sp and S.aureus isolates. Kill curves were performed at 8-16 x MIC, 2-4 x MIC and 0.5-1 x MIC over eight hours, with counts at time 0, 2h, 4h and 8h.

Results: MICs ranged from 1-2µg/ml. Average killing was 2.3 logs for coagulase-negative Staphylococcus sp. and 1.7 logs for S.aureus after 8h of exposure to concentrations >4 x MIC. The extent of killing did not correlate with the vancomycin concentration relative to the MIC of the organism as long as concentration was >2-4µg/ml.

Conclusions: Vancomycin killing of the ocular isolates was slow and variable. Vancomycin may not be the optimum drug to use.

OMIG Main Page | 2001 Abstracts| < Previous | Next>

Top of Page

Web Site Terms of Use | E-mail Terms of Use | Medical Advice Disclaimer
UPMC | Affiliated with the University of Pittsburgh Schools of the Health Sciences | Contact UPMC