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2003
OMIG, Abstract 13
OMIG
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Fungal
Colonization in Keratoprosthesis
Scott D. Barnes, Claes H. Dohlman, Barbara Paton, Marlene L. Durand
Purpose:
To determine the risk and incidence of fungal colonization in keratoprosthesis
(Kpro) patients.
Methods: After one case (out of 210 patients) of
fungal endophthalmitis, surveillance cultures were obtained in 80
keratoprosthesis patients from August 2002-July 2003. All patients
were using topical corticosteroids, fluoroquinolones, and fortified
vancomycin. The patient population included those with type I (normal
lid function over KPro) and type II (KPro extending through surgically
closed lid) devices with a mixture of medical diagnoses (Stevens-Johnson,
pemphigoid, ocular burns, and graft failure). Topical amphotericin
B was initiated in 5 of the patients.
Results: Fungal colonization was detected in 10
patients. The average time from date of surgery to date of positive
colonization was 18.6 months with a range of 3-57 months. No statistical
difference regarding type of Kpro was noted; however, there was
a trend toward positive cultures in the Stevens-Johnson and pemphigoid
patients compared to the ocular burn and graft failure groups.
Conclusions: Fungal colonization appears to be
more prevalent than originally thought. More frequent surveillance
of colonization and prophylactic Amphotericin B may be advisable.
OMIG
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