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2005 OMIG, Abstract 19

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Linezolid and Daptomycin: Future Ophthalmic Antibiotics?

E. G. Romanowski, R. P. Kowalski, F. S. Mah, Y. J. Gordon.

The Charles T. Campbell Ophthalmic Microbiology Laboratory, UPMC Eye Center, University of Pittsburgh, Pittsburgh, PA

Purpose. We evaluated the in vitro antibacterial activity of the Gram-positive antibiotics linezolid and daptomycin, and compared those with the in vitro antibacterial activity of other commonly used ophthalmic antibiotics used for Gram-positive ocular infections.

Methods. The Minimum Inhibitory Concentrations (MICs) of 25 consecutive Staphylococcus aureus endophthalmitis isolates and 25 consecutive Coagulase-Negative Staphylococci (CNS) endophthalmitis isolates were determined for linezolid (LZ), daptomycin (DP), moxifloxacin (MX), gatifloxacin (GA), gentamicin (GM), oxacillin (OX), erythromycin (E), vancomycin (VA), and cephalothm (CP) using E-tests. Susceptibility was interpreted using the CLSI standards. MIC5o and MIC9o determinations are expressed as ug/ml.

Results.

S. aureus LZ DP MX GA GM OX E VA CP
% Susceptible 100 100 72 64 96 40 32 100 100
MIC50 3 0.38 1.5 2 0.5 48 >256 1.5 1
MIC90 4 0.5 4 8 0.75 >256 >256 2 2

 

CNS LZ DP MX GA GM OX E VA CP
% Susceptible 100 100 72 76 84 24 32 100 100
MIC50 1.5 0.5 0.125 0.19 0.094 1 64 3 0.5
MIC90 2 0.75 32 64 6 6 >256 3 0.75

 

Conclusions. Linezolid and daptomycin, along with vancomycin and cephalothin (cefazolin), demonstrated 100% in vitro susceptibility for the Staphylococcus aureus and Coagulase- Negative Staphylococci endophthalmitis isolates tested. Our results suggest that further studies to determine the full potential of these antibiotics in ophthalmology are warranted.

Disclosure code:N

Support: NIH EY08227, EY08098

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