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2005
OMIG, Abstract 21
OMIG
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Effectiveness of Moxifloxacin
in the Treatment of Experimental Mycobacterium abscessus
Keratitis During LASIK Surgery.
.
A. Caballero1,
B. Thibodeaux1,
J. Wheeler2,
J. Reed1,
T. Kim3
and R. O'Callaghan1.
1LSU
Health Sciences Center in New Orleans. 2AIcon
Laboratories in Fort Worth. 3Duke
University Eye Center in Durham.
Purpose: To determine the effectiveness of the
fourth generation fluoroquinolone moxifloxacin for treatment of
M. abscessus keratitis during LASIK surgery using a rabbit
model of infection.
Methods: M. abscessus strain GS, a clinical
isolate, was used to infect rabbit corneas (104
CFU) during LASIK surgery. Dexamethasome phosphate was then injected
subconjunctivally (2 mg per eye). Two treatment schedules using
0.5% moxifloxacin (Vigamox) were followed: Treatment 1, eyes were
treated 30 minutes before infection (1 drop of antibiotic / eye
/10 minutes) and for four days post-infection (PI) (4 drops of antibiotic
/ eye / day, total of 19 drops); Treatment 2, eyes were treated
for four days post-infection (PI) (4 drops of antibiotic / eye /
day, total of 16 drops). Rabbits were sacrificed on day 5 PI and
corneas were harvested to determine the bacterial load (expressed
as log CFU).
Results: Treatment of eyes with Vigamox for 30
minutes before infection followed by treatment for four days PI
(Treatment 1) or for only 4 days PI (Treatment 2) resulted in
>4.64 log CFU reduction relative to untreated controls
(0.57±
0.36 and 1.64 ±0.60
versus 6.28±
0.11, respectively, p = 0.0001). Treatments 1 and 2 were equally
effective in decreasing the log CFU of bacteria in the infected
corneas (p = 0.1534).
Conclusions: Vigamox was very effective against
M. abscessus infection acquired during LASIK surgery.
This research was supported by the LSUHSC Foundation
Disclosure code: F
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