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2009 OMIG, Abstract 13

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Persistence of MRSA on Ocular Surface following Primary Infection.
D. Miller1, D. Almeida2, E. Alfonso1
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida1, Department of Ophthalmology, Queen’s University, Kingston, Ontario2

Purpose: To document the prevalence and persistence of MRSA colonization following primary ocular surface infections
Methods: Culture positive cases (N=23,793) were reviewed and repeat/persistent cases of MRSA identified and characterized by location and source over a 20 year period. Co-pathogens and trends in MRSA rates were also compiled.
Results:  Prevalence of MRSA among all Staphylococcus infections (N=3236) rose from 7.6% at baseline (1990-1994) to 34.6% during 2004-2009.  The general MRSA (N=669) rate increased by at least three fold among all ocular isolates. A cohort of 61 patients (9.1%) had repeat positive MRSA cultures and 67% remained colonized after multiple treatment regimens. Sixty seven percent (N=41) of persistent isolates were from patients with prior healthcare exposures; outpatient clinics (52.4%), ambulatory care/OR (11.8%) and inpatients (3.3%). Repeat isolates were more frequently recovered from the conjunctiva (N=26, 42.6%) and cornea (N=18, 29.5%). Nasal cultures from three patients with repeat cultures also revealed MRSA.  Co-pathogens among this cohort was 70.5% (N=43).
 Conclusions: Persistent and increasing recovery of MRSA from ocular surface could serve as a reservoir and transmission foci for post operative infections following, lasik, cataract and other ocular surgeries
Disclosure code: N

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