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2010 OMIG, Abstract 23

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Ophthalmic manifestations of human immunodeficiency virus infection in the era of highly active antiretroviral therapy
R. Sorenson1, B.H. Jeng1,2
1Dept. of Ophthalmology, University of California San Francisco and San Francisco General Hospital, San Francisco, CA, 2Francis I. Proctor Foundation, University of California San Francisco, CA

Purpose: Before the advent of highly active antiretroviral therapy (HAART), the rate of ophthalmic manifestations of human immunodeficiency virus (HIV) was very high.  We sought to determine if this rate has decreased in the HAART era. 
Methods: In this follow-up study to one performed at the same institution prior to the HAART-era, we retrospectively reviewed the charts of all HIV-positive patients who presented to the Eye Clinic of San Francisco General Hospital, a large, urban, tertiary care medical center with a comprehensive HIV treatment center, from July 1, 2008 to June 30, 2009.  Charts were reviewed for new onset of known ophthalmic manifestations of HIV infection, including HIV retinopathy, opportunistic infections, uveitis, and neoplasms. 
Results: The charts of 187 HIV-positive patients were available for review.  HIV retinopathy was found in 7 patients (3.7%).  There was one patient (0.5%) presenting with neurosyphilis with ocular involvement, but no cases of active cytomegalovirus retinitis were found.  Uveitis was found in 8 patients (4.3%), and ocular surface neoplasms were found in 2 patients (1.1%), including 1 case of conjunctival Kaposi sarcoma and 1 case of conjunctival squamous cell carcinoma. 
Conclusions: With an aggressive HIV treatment program in place utilizing HAART, the rate of ophthalmic manifestations of HIV infection appears to be lower than in the pre-HAART era in the same hospital population as from a previous study.

Disclosure Code:  N

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