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2011 OMIG Abstract 15

Development of a soft contact lens that releases antibiotics in a sustained manner
S. Kobayakawa1, T. Matsunaga2, Y. Yamazaki2, T. Sato2, T. Tochikubo1
1Toho University, Tokyo, Japan, 2SEED Co., Ltd., Tokyo, Japan

Purpose: We developed a new soft contact lens (SCL) of a hydrogel material capable of releasing antibiotics in a sustained manner. The purpose of this study was to investigate the penetration of the antibiotics into the aqueous humor by the drug released SCL (DR-SCL) in a rabbit model.

Methods: Gatifloxacin (GFLX) 0.3% and moxifloxacin (MFLX) 0.5% eye drops were used. As the DR-SCL, it was developed with a hydrogel that possessed the anionic group and the functional group as its side chain, the former capable of retaining drug and the latter of sustaining the release of drug. In Japanese albino rabbits, aqueous humor concentration of the antibiotics was measured with high-performance liquid chromatography (HPLC). Those samples were collected at 10, 30, and 60 minutes after three times topical administration at 15-min. intervals by those eye drops (eye drops group), and through the application with DR-SCL (DR-SCL group), also collected at 24, 48, and 72 hours through the application with DR-SCL.

Results:  The maximum GFLX concentration in aqueous humor were 1.13μg/ml (at 60 min.), and the MFLX concentration were 6.37μg/ml (at 60 min.) in the eye drops group. Those in the DR-SCL group, however, were 13.35μg/ml (at 60 min.) and 59.65μg/ml (at 60 min.), respectively. Those antibiotics concentrations in aqueous humor were significant differences between the eye drops group and the  DR-SCL groups at 60 min. Those concentrations for GFLX in the DR-SCL group decreased from 2.61μg/ml to 0.08μg/ml through 72 hours, and those for MFLX decreased from 7.85μg/ml to 3.16μg/ml through 72 hours.

Conclusions: Those antibiotics concentrations in aqueous humor in the DR-SCL group were approximately 10 times higher than those in the eye drops group. Moreover, DR-SCL sustained release of antibiotics through 72 hours. It was suggested that DR-SCL may be used for the prevention of acute postoperative endophthalmitis.  

Disclosures: N

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