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2011 OMIG Abstract 23

Clinicopathologic correlation of ocular surface squamous neoplasms at
Bascom Palmer Eye Institute: 2001 – 2010

A.A. Kao1, A. Galor1, C.L. Karp1, S.R. Dubovy1,2
1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, FL, 2Department of Pathology, University of Miami, Miami, FL

Purpose: The purpose of this study is to describe the clinical and histologic characteristics of ocular surface squamous neoplasm (OSSN) lesions and provide clinicopathologic correlation to determine clinical features that may indicate higher-grade lesions.

Design: Retrospective case series.

Participants: 612 consecutive OSSN lesions sent to the Bascom Palmer ocular pathology laboratory from January 1, 2001 to September 20, 2010.

Methods: Review of pathology records and patient charts.

Main Outcome Measures: Correlation of clinical factors and higher-grade OSSN on histology.

Results: Over the studied period, 33% of submitted specimens were characterized as mild, moderate or severe dysplasia; 52% were classified as carcinoma-in-situ and 11% were graded as squamous cell carcinoma. Characteristics associated with higher-grade OSSN lesions included male gender, biopsy at our institution, temporal and superior locations, involvement of the tarsus, lack of corneal involvement, papillomatous and nodular lesions, microscopic multifocality, and positive margins on biopsy.

Conclusions: Certain clinical factors are associated with higher-grade histologic lesions. These findings may help clinicians more accurately evaluate and anticipate the pathologic grade of conjunctival and corneal lesions suspected to be OSSN.

Supported by: The Florida Lions Eye Bank; the sponsor had no role in the design or conduct of this research.

Disclosures: N

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