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2012 Agenda and Abstracts | < Previous | Next >

2012 OMIG Abstract 8

Varicella-Zoster Virus Detection in Varicella-Associated Stromal Keratitis
A. Matoba1, B. Meghpara1, P. Chevez-Barrios2
1Baylor College of Medicine; 2The Methodist Hospital, Houston TX

Purpose: To report the detection of varicella-zoster virus (VZV) in the cornea of a patient with stromal keratitis following primary systemic infection with VZV.

Methods: Observational case report.

Results: A nine year old girl developed nonsuppurative stromal keratitis (NSSK) 3 months following varicella. The keratitis initially responded to topical corticosteroid therapy but she eventually developed increased inflammation which led to significant scarring. A penetrating keratoplasty was performed. Histopathological evaluation revealed scattered chronic lymphocytic infiltrates throughout the stroma and focally degenerated endothelium. Varicella-zoster virus (VZV) was detected by PCR in the deep stroma of the corneal button.

Conclusion: We believe that this is the first PCR-proven case of NSSK associated VZV following varicella infection.

Disclosure: This study was supported by an unrestricted grant from Research to Prevent Blindness, New York, NY.

2012 Agenda and Abstracts | < Previous | Next >