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2013 Agenda and Abstracts | Next >

2013 OMIG Abstract 1

The Epidemiology of Ocular Surface Squamous Neoplasia in
a Veterans Affairs Population

Andrew J. McClellan, MD1,2; Allison L. McClellan, OD1; Candido F. Pezon, BS1, Carol L. Karp, MD2,
William Feuer, MS2; Anat Galor, MD, MSPH1,2
1Miami Veteran Affairs Medical Center, Miami, FL, USA; 2Department of Ophthalmology,
Bascom Palmer Eye Institute, University of Miami, Miami, FL

Purpose: To evaluate the epidemiology of ocular surface squamous neoplasia (OSSN) and its associated risk factors in a South Florida Veterans Affairs Hospital population.

Design: Retrospective case-control study.

Methods: Participants: 28 confirmed cases of OSSN from 24,179 veterans who received care at the Miami Veterans Affairs Healthcare System (VA) and affiliated satellite eye clinics between March 1, 2007, and March 1, 2012. Methods: Data extracted from the veterans administration database comprised of demographic information and medical diagnosis information (based on International Classification of Disease (ICD-9) codes). Main Outcome Measures: The period prevalence of OSSN and identification of factors associated with the presence of disease.

Results: The period prevalence of OSSN in our population was 0.1%. Studied risk factors included human immunodeficiency virus (HIV) seropositivity, human papilloma virus (HPV)-related diseases, tobacco use, ultra-violet (UV)-related dermatologic diseases (melanoma, squamous and basal cell cancer, and actinic keratosis), and UV-related ocular conditions (pterygium). The presence of a skin malignancy (squamous cell
carcinoma (SCC) and/or basal cell carcinoma (BCC)) and pterygium were found to be significantly associated with the presence of OSSN (odds ratio (OR) 4.40, 95% confidence interval (CI) 2.03-9.55, p<0.0005 and OR 16.2 95% CI 7.11-36.9, p<0.0005, respectively).

Conclusions: The presence of neoplasias and ocular conditions related to sun exposure were the most important risk factors for the presence of OSSN in a South Florida VA population consistent with previous epidemiological reports worldwide.

Financial Disclosures: This study was supported by a grant from the Veterans Affairs medical center career development award > 10,000 (AG), NIH Center Core Grant P30EY014801, Research to Prevent Blindness Unrestricted Grant, Department of Defense (DOD-Grant#W81XWH-09-1-0675),
and contributions from B&L < 10,000 (AG).

2013 Agenda and Abstracts | Next >