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2017 Agenda and Abstracts | < Previous Next >

 

2017 OMIG Abstract 17

3 Month Continuous Release of Therapeutic Levels of Latanaprost
from Episcleral Collagen Wafers In The Rabbit

Richard A Eiferman, MD, FACS1, Dale P Devore, PhD2
1University Of Louisville, Louisville, Kentucky;
2DV Consulting, Boston, Massachusetts

 

Purpose:  To demonstrate a novel drug delivery system for sustained release of latanaprost in vivo.

Method: 25 ug of 3H latanaprost and 500 ug of ”cold” latanaprost were added to a specially prepared cross-linked collagen wafer.  The rabbits were anesthetized and an incision was made in the conjunctiva.  The wafers were inserted superiorly onto the sclera of albino rabbits in one eye; the other eye served as a control.  The incisions were closed with cautery.  Animals were sacrificed at 30, 60 and 90 days.  Test samples from aqueous (100µL), tear film (filter paper swipe), and saliva (filter paper swipe), blood (1mL), cornea, vitreous, and iris/ciliary body and placed in a liquid scintillation counter.

Results: 

Sample

30-day results

60-day results

90-day results

Aqueous treated

7.2ng

115pg

572pg

Aqueous Untreated Control

143pg

143pg

81pg

Conjunctival Tissue Treated

53ng

 140ng

9.1ng

Conjunctival Tissue Untreated Control

2.8ng

16.2ng

1.35ng

Blood

13.5ng/ml

No data

6.9ng/ml

Cornea Treated

506pg

7.82ng

172pg

Cornea Untreated Control

802pg

11.5ng

153ng

Iris/Ciliary Body Treated

3.86ng

11.2ng

334pg

Iris/Ciliary Body Untreated Control

1.35ng

9.51ng

296pg

Conclusion: There was continuous release of latanaprost at therapeutic levels from the episcleral collagen implant.  This method could eliminate the need for self administered eye drops to treat glaucoma. 

Disclosure:  P

 

2017 Agenda and Abstracts | < Previous Next >

 


 

 

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