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2004 OMIG, Abstract 14

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In vitro Susceptibilities of Ocular Isolates Coagulase-Negative Staphylococci to Fluoroquinolones in Sao Paulo, Brazil
A Oliveira, AL Hofling-Lima, R Belfort, MF Gayoso. Universidade Federal de Sao Paulo, Departmento de Oftalmologia, Sao Paolo, Brazil

Purpose: To evaluate the fluoroquinolone susceptibilities of forty three ocular isolates coagulase-negative Staphylococci (CNS), identified at the Microbiology Laboratory - UNIFESP.
Design: Experimental laboratory investigation.
Methods: The Minimum Inhibitory Concentrations of 21 strains of methicillin-resistent coagulase-negative Slaphylococcus and 22 methicillin-sensitive coagulase-negative Staphylococcus were determined to ciprofloxacin, ofloxacin, gatifloxacin and moxifloxacin, using E-test method standardized by the National Committee for Clinical Laboratory Standards (NCCLS).

Results: The MICs90 (ug/ml) for 43 CNS Isolates to ciprofloxacin, ofloxacin, gatifloxacin and moxifloxacin were:
  Total Strain MIC90Cipro MIC90 Oflox MIC90 Gati MIC90 Moxi
MR SCN 21 32 32 2.0 3.0
MS SCN 22 0.25 1.0 0.125 0.125
SCN 43        



MR SCN = methicillin-resistent coagulase-negative Staphylococcus; MS SCN = methicillin-sensitive coagulase-negative Staphylococcus; SCN = coagulase-negative Staphylococcus.

Conclusion: Our results indicated that methicillin-sensitive CNS were more susceptible to quinolones than methicillin resistant CNS and that fourth generation fluorquinolones appear to be more potent covering bacterial resistance to second generation for the coagulase-negative Staphylococcal strains.

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