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2005 OMIG, Abstract 24

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Comparing the healing times of corneal epithelium after photorefractlve keratectomy while using topical gatifloxacin or moxifloxacin.

Brett D. Brimhall, MD, Eric Dudeahoefer, MD, Charles Reilly, MD, Robert Smith, MD, Wilford Hall Medical Center

Purpose: To compare the effects of commercial topical preparations of gatifloxacin and moxifloxacin on epithelial healing times after pnotorefractive keratectomy (PRK).

Methods: Prospective double blind study evaluated 68 patients and 136 eyes after standard PRK surgery. An 8.5 millimeter alcohol well was used to create consistently sized epithelial defects in both eyes prior to stromal ablation. Post surgical patients received randomized commercial preparations of topical gatifloxacin in one eye and topical moxifloxacin in the other, four times daily. The patients were followed with daily "hands-off exams until the time of epithelial closure. The healing time for each eye was recorded and a statistical comparison between the two medications was made to see if there was any relative difference in time to epithelial closure.

Results: Average time to epithelial closure for all eyes was 3.2 days. Eyes treated with gatifloxacin took an average or 3.2 days. Eyes treated with moxifloxacin took 3.1 days. An ANOVA analysis between the treated eyes demonstrated a p-value of 0.42.

Conclusions: Our larger- sized study failed to demonstrate any significant difference in epithelial healing times of post PRK patients when using topical preparations of either gatifloxacin or moxifloxacin. In the short term setting neither medication appears to be associated with clinically significant delay in epithelial healing rates.

Disclosure code:F
Alcon, Allergan

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