The Charles T. Campbell Eye Microbiology Lab
UPMCUniversity of Pittsburgh Schools of the Health Sciences
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Antibiotic Susceptibility E TEST : Keratitis Conjunctivitis Endophthalmitis

Susceptibility* of Bacterial Isolates from Keratitis to Common Antibiotics
(January 1, 2020 through December 31, 2021)

Staphylococcus aureus (MIC= ug/ml)

ANTIBIOTIC
#
MIN
Q1
MEDIAN
Q3
MAXIMUM
MIC SUSCEPTIBLE
MIC RESISTANT
VANCOMYCIN
64
0.38
0.75
.75
1.00
1.50
< 2
> 16
GENTAMICIN
64
0.064
0.125
0.19
0.19
4.00
< 4
> 16
MOXIFLOXACIN
59
0.023
0.047
0.094
.25
12.00
< 0.5
> 2
CEFOXITIN
62
3.0
4.0
4.0
24.0
128.0
< 4
> 8
CEFAZOLIN
62
0.38
0.75
1.00
2.25
96.00
NS
NS
* Antibiotic susceptibilities are based on serum concentrations and NOT concentrations achieved in the corneal tissue.

(#) = Number of isolates tested. NS= No Standards

 

Pseudomonas aeruginosa (MIC= ug/ml)

ANTIBIOTIC
#
MIN
Q1
MEDIAN
Q3
MAXIMUM
MIC SUSCEPTIBLE
MIC RESISTANT
TOBRAMYCIN
38
0.38
1.0
1.50
2.00
6.00
< 4
> 16
CEFTAZIDIME
38
0.75
1.375
1.50
2.0
4.00
< 8
> 32
CIPROFLOXACIN
38
0.017
0.064
0.094
0.125
1.00
< 0.5
> 2
POLYMYXIN B
38
0.75
1.50
1.75
2.25
6.0
< 2
> 8
* Antibiotic susceptibilities are based on serum concentrations and NOT concentrations achieved in the corneal tissue.

(#) = Number of isolates tested.

 

Coagulase Negative Staphylococcus (MIC= ug/ml)

ANTIBIOTIC
#
MIN
Q1
MEDIAN
Q3
MAXIMUM
MIC SUSCEPTIBLE
MIC RESISTANT
VANCOMYCIN
21
0.25
1.00
1.50
1.50
3.00
< 4
> 32
GENTAMICIN
21
0.03
0.09
0.25
19.0
192.00
< 4
> 16
MOXIFLOXACIN
21
0.03
0.47
2.00
36.00
64.00
< 0.5
> 2
CEFAZOLIN
21
0.25
0.50
1.5
3.00
12.00
NS
NS
* Antibiotic susceptibilities are based on serum concentrations and NOT concentrations achieved in the corneal tissue.

(#) = Number of isolates tested. NS= No Standards

 

Streptococcus viridans (MIC= ug/ml)

ANTIBIOTIC
#
MIN
Q1
MEDIAN
Q3
MAXIMUM
MIC SUSCEPTIBLE
MIC RESISTANT
VANCOMYCIN
14
0.25
0.47
0.50
0.81
2.00
<1
-
GENTAMICIN
8
0.38
1.06
2.0
12.75
32.00
< 4
> 16
MOXIFLOXACIN
14
0.064
0.094
0.125
0.19
0.38
<1
> 4
CEFAZOLIN
9
0.02
0.16
0.25
2.25
16
NS
NS
* Antibiotic susceptibilities are based on serum concentrations and NOT concentrations achieved in the corneal tissue.

(#) = Number of isolates tested. NS= No Standards

 

Other Gram Positive bacteria (MIC= ug/ml)

ANTIBIOTIC
#
MIN
Q1
MEDIAN
Q3
MAXIMUM
MIC SUSCEPTIBLE
MIC RESISTANT
VANCOMYCIN
12
0.38
0.38
0.5
1.0
1.5
<1
-
GENTAMICIN
6
0.0
0.8
2.5
60.0
96.0
< 4
> 16
MOXIFLOXACIN
10
0.094
0.174
.315
0.47
4.0
< 1
> 4
CEFAZOLIN
11
0.0
0.1
0.3
24.0
128
NS
NS
* Antibiotic susceptibilities are based on serum concentrations and NOT concentrations achieved in the corneal tissue.

(#) = Number of isolates tested. NS= No Standards

 

Other Gram Negative bacteria (MIC= ug/ml)

ANTIBIOTIC
#
MIN
Q1
MEDIAN
Q3
MAXIMUM
MIC SUSCEPTIBLE
MIC RESISTANT
TOBRAMYCIN
15
0.25
0.38
1.0
1.5
3.00
< 4
> 16
CEFTAZIDIME
14
0.064
0.125
0.19
1.0
3.0
< 8
> 32
CIPROFLOXACIN
14
0.012
0.021
0.032
0.33
4.00
< 1
> 4
POLYMYXIN B
13
0.00
0.63
1.00
4.75
32.00
< 2
> 8
* Antibiotic susceptibilities are based on serum concentrations and NOT concentrations achieved in the corneal tissue.

(#) = Number of isolates tested.

 

Moraxella (MIC= ug/ml)

ANTIBIOTIC
#
MIN
Q1
MEDIAN
Q3
MAXIMUM
   
TOBRAMYCIN
13
0.0160
0.2200
0.5000
0.6250
1.00
   
CEFTAZIDIME
12
0.0160
0.0470
0.0940
0.1250
0.3800
   
CIPROFLOXACIN
12
0.0080
0.0130
0.0195
0.0297
0.9600
   
POLYMYXIN B
12
0.1900
0.2500
0.3150
0.3800
0.7500
   
* Antibiotic susceptibilities are based on serum concentrations and NOT concentrations achieved in the corneal tissue.

(#) = Number of isolates tested.

 

 

 

Susceptibility* of Bacterial Isolates from Conjunctivitis to Common Antibiotics
(January 1, 2020 through December 31, 2021)

 

Staphylococcus aureus (MIC= ug/ml)

ANTIBIOTIC
#
MIN
Q1
MEDIAN
Q3
MAXIMUM
MIC SUSCEPTIBLE
MIC RESISTANT
MOXIFLOXACIN
45
0.03
0.05
0.09
2.0
64.00
< 0.5
> 2
CEFOXITIN
48
0.8
4.0
4.0
15.0
512.0
< 4
> 8
* Antibiotic susceptibilities are based on serum concentrations and NOT concentrations achieved in the corneal tissue.

(#) = Number of isolates tested. NS= No Standards

 

Other Gram Positive bacteria (MIC= ug/ml)

ANTIBIOTIC
#
MIN
Q1
MEDIAN
Q3
MAXIMUM
MIC SUSCEPTIBLE
MIC RESISTANT
MOXIFLOXACIN
10
0.064
0.19
0.25
0.25
0.50
< 1
> 4
* Antibiotic susceptibilities are based on serum concentrations and NOT concentrations achieved in the corneal tissue.

(#) = Number of isolates tested.

 

Gram Negative bacteria (MIC= ug/ml)

ANTIBIOTIC
#
MIN
Q1
MEDIAN
Q3
MAXIMUM
MIC SUSCEPTIBLE
MIC RESISTANT
TOBRAMYCIN
23
0.5
0.75
1.00
1.50
32
< 4
> 16
CIPROFLOXACIN
23
0.008
0.016
0.047
0.38
0.63
< 1
> 4
POLYMYXIN B
22
0.00
0.15
1.0
2.0
64
< 2
> 8
MOXIFLOXACIN
4
0.047
0.11
0.19
0.69
6.0
NS
NS
* Antibiotic susceptibilities are based on serum concentrations and NOT concentrations achieved in the corneal tissue.

(#) = Number of isolates tested. NS= No Standards

 

 

Susceptibility* of Bacterial Isolates from Endophthalmitis to Common Antibiotics
(January 1, 2020 through December 31, 2021)

 

Gram Positive bacteria (MIC= ug/ml)

ANTIBIOTIC
#
MIN
Q1
MEDIAN
Q3
MAXIMUM
MIC SUSCEPTIBLE
MIC RESISTANT
VANCOMYCIN
44
0.25
0.75
1.0
1.5
2.00
< 4
> 32
* Antibiotic susceptibilities are based on serum concentrations and NOT concentrations achieved in the corneal tissue.

(#) = Number of isolates tested.

 

 

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