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OMIG Main Page | 2001 Abstracts| < Previous | Next> Ocular
Toxicity of Povidone Iodine Eyedrops: An Experimental Study Purpose: To evaluate the ocular toxicity of povidone iodine eyedrops at a concentration of 2.5% and 0.5% and investigate the effects on corneal epithelial wound healing and histopathological alterations. Methods: Each group consisted of 20 rabbits. A central circular corneal epithelial defect of 6.5 mm diameter was created and the povidone iodine eye drops (2.5% and 0.5% respectively) instilled in the right eye and distilled watter in the left eye (control) of each rabbit each hour during three days. Biomicroscopical examinations were performed every day, focusing on the corneaconjunctival surface and the diameter of the lesion using fluoresceine eyedrops, photo documentation, and a computerized image analyzer. After the third day the rabbits were sacrificed and the excised corneas evaluated histopathologically. Statistical evaluation was performed using Friedman, Wicoxon and Mann-Whitney testrs. Results: The povidone iodine eyedrops at a concentration of 2.5% caused an increase in the would healing time (p<0.001) and conjunctivitis in 100% with mucous secreation in 80%, punctate keratitis in 40%, and discrete stromal edema in 10% of the cases. The histopathological examination showed corneal ulcers and vacuolic degeneration of the epithelial layer in 100% as well as an inflammatory infiltrate with eosinophils in 80% of the cases. The eyes treated with povidone iodine eyedrops at a concentration of 0.5% and the control eyes showed complete epithelial wound healing after 72 hours and histopathologically normal epitheliazation. Only in one case, a discrete leucocytic infiltrate was observed perilimbar. Conclusions:
The ocular toxicity of povidone iodine eyedrops is concentration-dependent.
The yes of the eyedrop at a concentration of 2.5% is not adequate
for daily and repetitive use. In contrast, at a concentration of
0.5% no toxicity was observed. OMIG Main Page | 2001 Abstracts| < Previous | Next>
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