The Charles T. Campbell Eye Microbiology Lab
UPMC | University of Pittsburgh Medical CenterUniversity of Pittsburgh Schools of the Health Sciences
HomeAbout UsLab Diagnostic TestingAntibiotic SusceptibilityAntimicrobial TherapyCurrent ResearchContact Us

2003 OMIG, Abstract 10

OMIG Main Page | 2003 Abstracts | < Previous | Next>

Human Aqueous Humor Penetration Pharmacokinetics of Moxifloxacin After Topical Administration of Moxifloxacin 0.5% Ophthalmic Solution
Katz HR1, Masket S2, Lane SS3, Sail K4, Orr SC5, McCue BA5, Faulkner RD5 Dahlin DC5. 1Krieger Eye Institute, Baltimore, Maryland; 2Private practice, Beverly Hills, California; 3Private practice, Stillwater, Minnesota; 4Private practice, Bellflower, California; 5Alcon, Inc., Fort Worth, Texas.

Purpose: To investigate the aqueous humor pharmacokinetics of Moxifloxacin 0.5% Ophthalmic Solution.
Methods: In this open-label, sparse-sampling, pharmacokinetic study at 4 U.S. centers, 60 adults requiring cataract surgery were randomly allocated to 1 of 2 treatment regimens of Moxifloxacin 0.5% Ophthalmic Solution. On the day of surgery, Group I (n=30) received a preoperative regimen of 1 drop every 15 minutes for 4 doses in the eye undergoing surgery. Group 2 (n=30) received 1 drop four times a day on the day before surgery, and on the day of surgery received the same preoperative regimen as Group I. In both groups, the last dose was administered either 0.25, 0.50, 1, 2, or 3 hours before aqueous humor sampling. In both groups, 6 samples (from 6 eyes) were obtained at each sampling time. Moxifloxacin concentrations in the aqueous humor were analyzed by HPLC/MS/MS.
Results: For Group 1, mean CMAX was 1.50±0.85 ug/mL (range 0.840 to 3.03ug/mL). For Group 2, mean CMAX was 1.74±0.66ug/mL (range 0.678 to 2.44ug/mL). Analysis of the complete data set is in progress.
Conclusion: Moxifloxacin 0.5% Ophthalmic Solution penetrates the cornea and enters the aqueous humor. The maximum concentration far exceeded the MIC values for S. aureus and for S. epidermidis.

OMIG Main Page | 2003 Abstracts | < Previous | Next>

Top of Page

Web Site Terms of Use | E-mail Terms of Use | Medical Advice Disclaimer
UPMC | Affiliated with the University of Pittsburgh Schools of the Health Sciences | Contact UPMC