|
2003
OMIG, Abstract 17
OMIG
Main Page | 2003
Abstracts | <
Previous | Next>
Ocular
Surface Squamos Neoplasia: The Standard of Care Survey
Donald U. Stone, James Chodosh. Dean McGee Eye Institute, OKC, OK
Purpose:
To determine current practice patterns for treatment of ocular surface
squamous neoplasia (OSSN) in the era of topical chemotherapeutics.
Methods: An introductory letter, survey, and stamped
return envelope were mailed to 345 physician members of the Ocular
Microbiology and Immunology Group (OMIG). Members were queried with
regards to their preferred form of therapy, their specific surgical
technique, and the possible use of topically applied treatments
including mitomycin C (MMC), interferon (IFN), and 5-fluorouracil
(5-FU).
Results: 122 surveys were completed and returned.
For initial treatment of OSSN, the majority of responders utilize
excision alone or excision with adjunctive topical therapy. Surgical
approach varied considerably, particularly with respect to ideal
surgical margins (mean: 2.4 mm, range: 1-5 mm). The proportion of
responders who felt there was sufficient evidence to support the
use of MMC, lFN, or 5-FU as the sole form of therapy for OSSN was
54, 21, and 11%, respectively. Taken together, 58% of OMIG physician
members felt the evidence was sufficient to support use of at least
1 of the 3 topical agents. Only half the responders (51%) always
perform a biopsy before instituting topical therapy. While 82% of
respondents replied that there should be a clinical trial of topical
agents, 83% believed a placebo arm was unnecessary or inappropriate
as part of such a study.
Conclusions: This survey demonstrates a wide disparity
in practice patterns for treatment of OSSN. Topical chemotherapy
appears to be used commonly, despite a lack of long term outcome
data. A prospective clinical trial is indicated to delineate the
optimal therapy for OSSN.
OMIG
Main Page | 2003
Abstracts | <
Previous | Next>
|
|
|