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2003 OMIG, Abstract 4

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In vitro Resistant Rates for Fluoroquinolones Against Methicillin Sensitive (MS) and Methicillin Resistant (MR) Staphylococcus aureus Ocular Isolates
Darlene Miller, Martha Diaz, Edith Perez, and Eduardo Alfonso.
Bascom Palmer Eye Institute, University of Miami, Miami, Fla

Purpose: To benchmark and compare emerging resistance among the current ophthalmic fluoroquinolones against Staphylococcus aureus ocular pathogens recovered from patients presenting at BPEI during the last three years.
Methods: E tests and disk diffusions tests were used to generate susceptibility patterns for 71 pathogens (45 MSSA, and 26 MRSA) against moxifloxacin, gatifloxacin, levofloxacin, ofloxacin and ciprofloxacin.
Results: Fluoroquinolones resistance was found in both methicillin sensitive and methicillin resistant isolates. Resistant rates for MSSA were: moxifloxacin (7%), gatifloxacin (9%), levofloxacin (13%), ofloxacin (16%) and ciprofloxacin (16%). For the MRSA isolates, in vitro resistance were: moxifloxacin (77%), gatifloxacin (81%), levofloxacin (81%), ciprofloxacin (88%) and ofloxacin (88%). In general, moxifloxacin provided coverage for 68% of the isolates and gatifloxacin 65%. Coverage by levofloxacin, ofloxacin and ciprofloxacin was 62%, 59% and 58%.
Conclusions: A high rate of in vitro resistance was documented for the fluoroquinolones against methicillin resistant S. aureus ocular isolates. Resistance among methicillin susceptible pathogens ranged from 7% to 16%. These laboratory results must be correlated with clinical treatment/outcome studies.

Supported in part by a grant from Research to Prevent Blindness
No financial interest in products for (Miller, Perez, Diaz)
Speaker for Alcon, Allergan, Santen (Alfonso)


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