Ocular Microbiology and Immunology Group
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2014 OMIG Abstract 8

Effect of Moxifloxacin on Fungal Keratitis
Ryan Barrett MD; Anna Lehmann; Alice Matoba MD
Department of Ophthalmology, Baylor College of Medicine, Houston, TX

Purpose: To further characterize the effect of moxifloxacin on fungal keratitis, following a previous report of cure of five cases with moxifloxacin monotherapy.

Methods: A retrospective review of patients with culture-proven fungal keratitis who were initially treated with moxifloxacin was performed. The time period studied was July 2012 through June 2014.

Results: Eleven patients who later were documented to have culture-confirmed fungal keratitis were initially treated with moxifloxacin for a variety of circumstances. Three patients (one case each of Curvularia, Alternaria, Paecilomyces) had a marked response within a few days and ultimately were cured. Eight patients had modest to no improvement and were switched to natamycin with cure.

Conclusion: Initial improvement of microbial keratitis with fluoroquinolone therapy does not rule out fungal keratitis. Moxifloxacin has some clinical antifungal effect.

Disclosure: N

2014 Agenda and Abstracts | < Previous | Next >