The Charles T. Campbell Eye Microbiology Lab
UPMCUniversity of Pittsburgh Schools of the Health Sciences
HomeContact InformationLab Diagnostic TestingAntibiotic SusceptibilityAntimicrobial TherapyCurrent ResearchPhotos

Ocular Microbiology and Immunology Group
Back to OMIG Main Page

2015 Agenda and Abstracts | < Previous | Next >

2015 OMIG Abstract 25

Dry Eye Profiles in Patients with a Positive Elevated Surface Matrix Metallopeptidase 9 Point of Care Test versus Negative Patients
Victoria S. Chang MD1, Nicole Lai Lanza MEd1,2, Felipe Valenzuela  MD1, Victor L Perez MD1,
Anat Galor MD, MSPH1,2
1Bascom Palmer Eye Institute, University of Miami, 900 NW 17th Street, Miami, FL, 33136
2Miami Veterans Administration Medical Center, 1201 NW 16th St, Miami, FL 33125

PURPOSE:  To compare dry eye symptoms and signs in patients who tested positive versus those who tested negative for ocular surface matrix metallopeptidase 9 (MMP-9) using the InflammaDry point of care test (RPS, Tampa, FL).

METHODS: In this cross-sectional study, individuals with dry eye symptoms, as evidenced by dry eye questionnaire 5 (DEQ5) seen in the Miami Veterans Affairs eye clinic, were given standardized questionnaires to assess dry eye symptoms and ocular and non-ocular pain complaints.  Also, a complete evaluation was conducted to measure ocular surface signs of dry eye.  MMP-9 testing was performed using the InflammaDry once in each eye, per the manufacturer’s instructions.  Our main outcome measure was the comparison of dry eye symptoms and signs in MMP-9 positive versus negative patients. 

RESULTS:  Of 110 patients, 43 (39%) were positive for MMP-9 for InflammaDry testing in either eye.  No statistically significant differences in demographics, co-morbidities, psychiatric status, ocular surface symptoms, and signs of dry eye were seen in patients based on MMP-9 status.

CONCLUSIONS: In our population, there was no difference in dry eye profile in both signs and symptoms between those testing positive versus negative for MMP-9 on the ocular surface. 


2015 Agenda and Abstracts | < Previous | Next >