Ocular Microbiology and Immunology Group
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2015 OMIG Abstract 25

Dry Eye Profiles in Patients with a Positive Elevated Surface Matrix Metallopeptidase 9 Point of Care Test versus Negative Patients
Victoria S. Chang MD¹, Nicole Lai Lanza MEd^1,2, Felipe Valenzuela  MD¹, Victor L Perez MD¹,
Anat Galor MD, MSPH^1,2
1Bascom Palmer Eye Institute, University of Miami, 900 NW 17th Street, Miami, FL, 33136
²Miami Veterans Administration Medical Center, 1201 NW 16th St, Miami, FL 33125

PURPOSE:  To compare dry eye symptoms and signs in patients who tested positive versus those who tested negative for ocular surface matrix metallopeptidase 9 (MMP-9) using the InflammaDry point of care test (RPS, Tampa, FL).

METHODS: In this cross-sectional study, individuals with dry eye symptoms, as evidenced by dry eye questionnaire 5 (DEQ5) seen in the Miami Veterans Affairs eye clinic, were given standardized questionnaires to assess dry eye symptoms and ocular and non-ocular pain complaints.  Also, a complete evaluation was conducted to measure ocular surface signs of dry eye.  MMP-9 testing was performed using the InflammaDry once in each eye, per the manufacturer’s instructions.  Our main outcome measure was the comparison of dry eye symptoms and signs in MMP-9 positive versus negative patients. 

RESULTS:  Of 110 patients, 43 (39%) were positive for MMP-9 for InflammaDry testing in either eye.  No statistically significant differences in demographics, co-morbidities, psychiatric status, ocular surface symptoms, and signs of dry eye were seen in patients based on MMP-9 status.

CONCLUSIONS: In our population, there was no difference in dry eye profile in both signs and symptoms between those testing positive versus negative for MMP-9 on the ocular surface. 

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2015 Agenda and Abstracts | < Previous | Next >