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2018 Agenda and Abstracts | < Previous Next >

2018 OMIG Abstract

Comparison of Post-Herpetic and Post-Refractive Surgery-Related Corneal Neuralgia

Mehmet Cuneyt Ozmen, NeslihanDilruba Koseoglu, Pedram Hamrah
CorneaDivision, New England Eye Center, Tufts Medical Center and Center for Translational Ocular Immunology, Tufts University Medical School


Purpose: To compare clinical characteristics ofneuropathic corneal pain due to herpetic eye disease and refractive surgery.

Methods: Retrospective chart review of patients with NCP due to herpes simplex virus (HSV)keratitis or herpes zoster ophthalmicus (HZO), photo-refractive keratectomy (PRK), or laser in-situ keratomileusis (LASIK) was performed. Age, sex, patient-reported pain levels at the first visit according to the visual analogue scale (VAS), ocular pain assessment survey (OPAS),quality of life (QoL), Ocular Surface Disease Index (OSDI) score,presence or absence of symptoms of pain, photoallodynia, burning, and dryness were recorded.Patients who had HSV keratitis or HZO were analyzed in the post-herpetic neuralgia (PHN) group whereas patients who had refractive surgery were analyzed as post-refractive surgery neuralgia (PRSN). Differences between groups were assessed using chi-square analysis for categorical data and Wilcoxon signed-rank test for continuous data.

Results: There were 8 patientsin the PHN and 23 patients in the PRSN groups.Mean age was 66.0?11.06 for the PHN group and 37.3?13.16 for the PRSN group (p<0.001). There was no significant difference in sex distribution between the groups (p=0.750).There was no significant difference in mean VAS between the groups (4.75?1.83 and 6.31?2.99 for the PHN and PRSN groups, respectively, p=0.129). The impact of PHN and PRSN on QoL were comparable (p=0.153).Mean OSDI scores were 62.42?19.55 and 61.11?20.16 for PHN patients and PRN patients respectively (p=0.935). Pain was present in all patients of both groups. Photoallodynia was present in 50.0% of PHN patients and 69.6% of PRN patients (p=0.405). Dryness was reported by 75.0% of PHN patients and 69.6% of PRN patients (p=0.771). Burning sensation was reported by62.5% of PHN patients and 52.2% of PRN patients (p=0.613).

Conclusion: Post-refractive surgery neuralgia patients have symptoms similar or worse to post-herpetic neuralgia patients,having a comparable effect on QoL. Interestingly photoallodynia was more prevalent in PRSN patients.

Disclosure: N (MCO, NDK); P,C,S (PH)


2018 Agenda and Abstracts | < Previous Next >