Ocular Microbiology and Immunology Group
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2019 OMIG Abstract

What is the Prevalence of Bacteria, Fungi, Viruses, and Acanthamoeba from Cases of Keratitis, Endophthalmitis, and Conjunctivitis?

Regis P. Kowalski, MS, M(ASCP), Shannon V Nayyar, BS, M(ASCP), Eric G. Romanowski, MS,
Robert M.Q. Shanks, PhD, Alex Mammen, MD, Deepinder K. Dhaliwal, MD, Vishal Jhanji , MD
The Charles T. Campbell Laboratory, UPMC, Ophthalmology, University of Pittsburgh, Pittsburgh, PA

Methods: Data used for laboratory certification were reviewed for the detection of bacteria, viruses, fungi, and protozoa, from patients with infectious keratitis, endophthalmitis, and conjunctivitis. The main outcome parameter was laboratory-positive ocular infection.

Results: The distribution of infectious agents for keratitis (n=1387) (2004-2018) was bacteria 72.1% (Staphylococcus aureus 20.3%, Pseudomonas aeruginosa 18%, Streptococcus spp. 8.5%, other Gram-Positives 12.4%, and other Gram-Negatives 12.9%), Herpes simplex virus 16%, fungi 6.7%, and Acanthamoeba 5.2%. For endophthalmitis, (n=770) (1993-2018), the bacterial distribution was Coagulase Negative Staphylococcus 54%, Streptococcus spp. 21%, Staphylococcus aureus 10%, other Gram-Positives 8%, and Gram-Negatives 7%. The distribution for conjunctivitis (n=847) (2004-2018) was Adenovirus 34%, Staphylococcus aureus 25.5%, Streptococcus pneumoniae 9%, Haemophilus 9%, other Gram-Negatives 8.8%, other Gram-Positives 6%, Coagulase Negative Staphylococcus 4.5% and Chlamydia 3.2%.

Conclusion: An updated monitoring of ocular pathogens creates an awareness of the different infectious etiologies and the importance of laboratory studies. This information can determine treatment needs for infectious ocular disease.

Disclosure: N

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