The Charles T. Campbell Eye Microbiology Lab
UPMCUniversity of Pittsburgh Schools of the Health Sciences
HomeContact InformationLab Diagnostic TestingAntibiotic SusceptibilityAntimicrobial TherapyCurrent ResearchPhotos

Ocular Microbiology and Immunology Group
Back to OMIG Main Page

< Previous | 2020 Agenda and Abstracts | Next >


2020 OMIG Abstract

Pythium Keratitis: Outcome and Prognostic Factors

Bhupesh Bagga, FRCS1, Anahita Kate, MD1, Savitri Sharma, MD2, Ashik Mohamed, PhD3
1The Cornea Institute, L V Prasad Eye Institute, Hyderabad, India; 2Jhaveri Microbiology Centre, LV Prasad Eye Institute, Hyderabad, India; Cornea Institute, 3Biophysics, L V Prasad Eye Institute, Hyderabad, India

Purpose: To describe the outcome and prognostic factors of Pythium keratitis.

Methods: Retrospective analysis of 69 cases with microbiologically confirmed Pythium keratitis, managed between January 2017 to October 2018, was performed. All cases had been treated with topical linezolid 0.2 % ophthalmic solution and topical azithromycin 1% or ointment 1% along with Oral azithromycin 500 mg.

Results: The mean age was 38.4+14.7 years and median logMAR visual acuity was 2.78 (1.20-3.00). Average size of the infiltrate was 5.5x5.6 mm. Out of 69 cases, 37/69 (53.6%) cases showed clinical resolution. Median duration of resolution of keratitis with medical treatment was 3 (IQR, 2-4) months. Median LogMAR final visual acuity improved to 0.80 (IQR, 0.40-1.60). While posterior stromal involvement was associated with worse outcome (p=0.04), presence of pinhead lesions surrounding the infiltrate (P=0.04) and plaque like infiltrate (P=0.16) were associated with successful outcome. Therapeutic keratoplasty was needed in 32/69 (46.3%) cases either for tectonic support in a responding keratitis or for worsening of infection. None of the case had any residual or recurrence of infection after keratoplasty.

Conclusion: This case series has provided evidence regarding the potential role of antibiotics in the management of Pythium insidiosum keratitis and highlighted features for prognostication of the disease.

Disclosure: N

Support: Hyderabad Eye Research Foundation



< Previous | 2020 Agenda and Abstracts | Next >