2002
Ocular Microbiology and Immunology Group, Abstract 2
OMIG
Main Page | 2002
Abstracts | <
Previous | Next>
Comparative
efficacy of topical gatifloxacin, a new fluoroquinolone, versus
topical ciprofloxacin, penicillin G and tobramycin in the treatment
of experimental S. pneumoniae and P. aeruginosa keratitis in rabbits.
Myung-Jin Joo M.D., Elias Aliprandis M.D., Terrence P. O'Brien M.D.
Ocular Microbiology Laboratory, The Wilmer Eye Institute, Johns
Hopkins University School of Medicine, Baltimore, Maryland, USA
Purpose:
To examine the comparative efficacy of gatifloxacin, a new topical
fluoroquinolone, against experimental keratitis due to Streptococcus
pneumoniae and Pseudomonas aeruginosa keratitis in a rabbit model.
Methods:
Forty New Zealand albino rabbits were divided in two experimental
groups. Bacterial keratitis was created in the right eye with central
corneal intrastromal injection of a 100 microliter suspension containing
1 X 106 organisms of ATCC strains of Streptococcus pneumoniae and
Pseudomonas aeruginosa, respectively. To compare the drug efficacy
of gatifloxacin with other antibiotic agents, the Streptococcus
pneumoniae keratitis group received topical gatifloxacin 0.3% or
ciprofloxacin 0.3% or penicillin G 500,000 u/ml, or non-bacteriostatic
balanced salt solution as a control administered every hour for
12 hours. The Pseudomonas aeruginosa keratitis group received gatifloxacin
0.3%, ciprofloxacin 0.3%, tobramycin 14.5 mg/ml or control (BSS).
The corneas were excised and ground for quantitative bacteriologic
analysis.
Results:
All treatments significantly reduced the number of organisms in
treated eyes compared to untreated, control eyes (p-values <
0.05). No significant difference in treatment efficacy was found
between individual treatment groups.
Conclusion:
Gatifloxacin may prove useful as a broad-spectrum topical antibiotic
in the empiric treatment of bacterial keratitis, given its greater
Gram positive coverage including S. pneumoniae as well as its excellent
activity against Gram negative organisms, including Pseudomonas
species.
OMIG
Main Page | 2002
Abstracts | <
Previous | Next>
|