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2002 Ocular Microbiology and Immunology Group, Abstract 8

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Prophylaxis of Streptococcus Pneumoniae keratitis with Gatifloxacin in a Rabbit LASIK Model
Robert S. Donnenfeld,1 Jonathan J. Stein, MD,1 Harold G. Jensen, PhD,2 Henry D.Perry, MD,1 Renee Solomon, MD,1 Robert Snyder, MD,3 John Wittpenn, MD1
1Department of Ophthalmology, Nassau University Medical Center, East Meadow, NY, 2Allergan Pharmaceutical, Irvine, CA, 3University of Arizona, Tucson, AZ

Purpose: To investigate the efficacy of Gatifloxacin as compared to Ciprofloxacin in preventing Streptococcus pneumoniae keratitis in a rabbit LASIK model.

Methods: Twelve Albino rabbits had bilateral lamellar flaps created. Group A (8 eyes) was given Gatifloxacin 0.3%, Group B (8 eyes) was given Ciprofloxacin 0.3% and Group C (8 eyes) served as the control. Group A and B received one drop of antibiotic 20 minutes prior to the lamellar flap, at the conclusion of flap formation, and qid for three days. All corneas were inoculated with 0.1cc of 4 x 105 organisms/mL of Streptococcus pneumoniae immediately following flap formation. On day 3 all corneas were evaluated and cultured.

Results: Group A (Gatifloxacin) had no infiltrates and 3 areas of 1 mm central corneal haze. On day 3 one of eight rabbits had positive cultures. Group B (Ciprofloxacin) had 7 infiltrates including one perforation and 6 of 8 had positive cultures. Group C had 8 comeal infiltrates and all 8 had positive cultures.

Conclusion: Gatifloxacin 0.3% is superior to Ciprofloxacin 0.3% for prophylaxis against Streptococcus pneumonaie in a rabbit LASIK model.

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