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2003
OMIG, Abstract 1
OMIG
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The
In Vitro Evaluation of the Ophthalmic Fluoroquinolones Against Bacterial
Conjunctivitis Isolates
EG Romanowski, RP Kowalski, KA Yates, FS Mah, YJ Gordon. The Charles
T. Campbell Laboratory, University of Pittsburgh, Pittsburgh, PA.
Purpose:
We determined the in vitro susceptibilities and antimicrobial activities,
based on the MICs, of recent conjunctivitis isolates against the
5 ophthalmic fluoroquinolones (FQ) (ciprofloxacin [C], ofloxacin
[O], levofloxacin [L], gatifloxacin [G], moxifloxacin [M]).
Methods: The MICs of 90 bacterial conjunctivitis
isolates (8/98-9/02) were determined using Etests. The antibiotic
susceptibilities were determined using the NCCLS standards. The
in vitro susceptibilities and MICs were compared statistically.
Results:
| |
Median
MIC (µg/ml) |
|
Bacteria |
C |
O |
L |
G |
M |
Suscept. |
S.
aureus QR (20) |
64 |
64 |
64 |
6.0 |
2.0 |
M>C=O=L=G |
(% Susceptible) |
(0) |
(0) |
(0) |
(0) |
(40) |
|
S.
aureus QS (20) |
0.38 |
0.5 |
0.25 |
0.125 |
0.064 |
C=O=L=G=M |
(%
Susceptible) |
(100) |
(100) |
(100) |
(100) |
(100) |
|
St.
pneumoniae (20) |
0.38 |
1.0 |
0.38 |
0.125 |
0.064 |
C=O=L=G=M |
(%
Susceptible) |
(95) |
(90) |
(100) |
(100) |
(100) |
|
alpha-Strep
(5) |
1.0 |
2.0 |
0.8 |
0.25 |
0.125 |
C=O=L=G=M |
(%
Susceptible) |
(60) |
(80) |
(80) |
(80) |
(100) |
|
| Haemophilus
sp. (20) |
0.016 |
0.056 |
0.023 |
0.016 |
0.047 |
C=O=L=G=M |
| (% Susceptible) |
(100) |
(90) |
(100) |
(100) |
(100) |
|
| B. catarrhalis
(5) |
0.023 |
0.094 |
0.032 |
0.023 |
0.032 |
C=O=L=G=M |
| (% Susceptible) |
(100) |
(100) |
(100) |
(100) |
(100) |
|
| QR,
QS = Resistant or susceptible to ciprofloxacin and ofloxacin
by disc diffusion. |
Conclusions:
G and M had lower MICs against Gram-positive pathogens over C, O,
and L, but no advantage against Gram-negative pathogens. Only M
showed an increased in vitro susceptibility for 1 pathogen (S. aureus
QR) compared to all other FQ. All other susceptibilities were equal.
Clinical usage will define the significance of in vitro studies.
Support: The
Campbell Laboratory and NIH Core Grant EY08098.
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