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2003 OMIG, Abstract 2

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In Vitro Susceptibility and Minimal Inhibitory Concentration Data for Ocular Pathogens for Gatifloxacin in Comparison with 4 Other Fluoroquinolones
B. Fouraker1, M. Callegan2, M. Desjardins3, H. Perry4, L. Villanueva5, H. Jensen5. 1Brandon Eye Clinic, Brandon, Fl, 2Dean A. McGee Eye Institute, Oklahoma City, OK, 3Ottawa Hospital, Ottawa, Ontario, Canada, 4Ophthalmic Consultants of Long Island, Rockville Center, NY, 5Allergan Inc., Irvine, CA

Purpose: To compare the susceptibilities and minimal inhibitory concentrations of a variety of ocular pathogens to gatifloxacin with those of other fluoroquinolones.
Methods: A total of 433 bacterial ocular pathogen isolates collected from January through December of 2002 were analyzed at 4 laboratory sites in the US and Canada. Minimum inhibitory concentrations (MIC) were determined for gatifloxacin (GAT), moxifloxacin (MOX), ciprofloxacin (CIP), levofloxacin (LEV), and ofloxacin (OFL) according to NCCLS definitions using the quantitative E-test.
Results: The MIC90 of GAT and MOX for all isolates were equal (2.0mg/L) and were less than those of CIP, LEV, and OFL (32.0, 15.6, and 32.0 mg/L, respectively). The percentages of susceptible isolates (n=433) were as follows: GAT, 91.2%; MOX, 90.5%; CIP, 80.1%; LEV, 85.2%; and OFL, 80.1%. For the Gram-negative organisms (n=171), the percentages of susceptibilities of the isolates for each agent were as follows: GAT, 98.2%; MOX, 97.1%, CIP, 94.7%; LEV, 95.9%; and OFL, 95.3%. For the Gram-positive organisms (n=262), the percentages of susceptibility results were GAT, 86.6%; MOX, 86.3%; CIP, 70.6%; LEV, 78.2%; and OFL, 70.2%. S. aureus was the most common pathogen (19.9%), followed by S. epidermidis (18.5%), H. influenzae (15.0%), P. aeruginosa (7.2%), S. pneumoniae (6.2%), and other bacterial species (each <5% of total).
Conclusions: The MIC values for the 4th-generation fluoroquinolones, GAT and MOX, were lower than those for earlier generations of fluoroquinolones (CIP, LEV, and OFL), and the susceptibilities of all isolates to GAT and MOX were greater than CIP, LEV, and OFL.

Financial Support: This study was supported by Allergan, Inc.

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