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2003
OMIG, Abstract 21
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The
Threat of Atypical Mycobacteria in Ophthalmology
Barry A. Schlech1, David W. Stroman1, Eduardo Alfonso2, Kirk WiIheImus3
and Robert L. Abshire1.
1AIcon Research, Ltd., Fart Worth, Texas; 2Bascom Palmer Eye Institute,
University of Miami, Miami, Florida,
3Department of Ophthalmology, Baylor College of Medicine, Houston,
Texas
Purpose:
To assess the relative pathology of atypical (non-tuberculous) mycobacteria
in ocular infections and the in vitro antibacterial activity of
newer antibiotics against these organisms.
Methods: Comparison of the susceptibility to fluoroquinolones
of a variety of atypical (non-tuberculous) Mycobacterium species,
taxonomic and growth characteristics, as well as incidence in ocular
infections.
Results: Of the fluoroquinolones, moxifloxacin
had one of the lowest MICs against Mycobacterium fortuitum, M. chelonae
and M. avium. The peculiar incidence of atypical mycobacteria in
ocular post-LASIK infections is balanced by the potential of 4th
generation fluoroquinolones to treat and prevent these infections.
Conclusions: The fluoroquinolone family of antibiotics,
and moxifloxacin in particular, has properties favorable for the
treatment and prevention of ocular infections caused by atypical
(non-tuberculous) mycobacteria, including M. chelonae and M. fortuitum.
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