2003 OMIG, Abstract 24

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Safety of Prophylactic Intracameral Gatifloxacin in Cataract Surgery
E.D. Donnenfeld^1,4, R.W. Snyder², A.J. Kanellopoulos³, H.D.Perry¹, C. Cheng⁴, J. Wittpenn¹, C. Roberts^5
1Nassau University Medical Center, ²University of Arizona, ³University of Athens, Greece, ⁴Manhattan Eye Ear and Throat Hospital, ⁵Cornell University Medical Center

Purpose: To determine the safety and efficacy of intracameral gatifloxacin at the conclusion of cataract surgery.
Methods: 40 patients undergoing routine cataract surgery were given 0.10cc containing 100umg of intracameral gatifloxacin at the conclusion of clear corneal incision cataract surgery. All patients had preoperative evaluations of corneal clarity, ultrasonic pachymetry, endothelial cell counts, JOP, and BCVA. These parameters were evaluated at 1 day, 1 week, 1 month, and 3 months following surgery except for endothelial cell counts which were evaluated at the 1 month and 3 month postoperative visits.
Results: 7 patients had grade 1-2 corneal edema on the first postoperative visit. On all subsequent examinations all of the corneas were clear and compact with no significant change in ultrasonic pachymetry. There was a mean decrease in endothelial cell counts of 6 percent at 1 month and 7 percent at 3 months. There was a mean increase in IOP of 6mm Hg at the first postoperative visit (p<0.001) and no significant changes in IOP on subsequent visits. BCVA improved from a mean of 20/74 preoperatively to 20/24 at 1 week and 20/22 at 1 month and 3 months.
Conclusions: Intracameral gatifloxacin appears to be safe and well tolerated at a concentration of 100umg in 0.1cc at the conclusion of cataract surgery. Further studies are indicated.

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