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2004
OMIG, Abstract 14
OMIG
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In
vitro Susceptibilities of Ocular Isolates Coagulase-Negative Staphylococci
to Fluoroquinolones in Sao Paulo, Brazil
A Oliveira, AL Hofling-Lima, R Belfort, MF Gayoso. Universidade
Federal de Sao Paulo, Departmento de Oftalmologia, Sao Paolo, Brazil
Purpose:
To evaluate the fluoroquinolone susceptibilities of forty three
ocular isolates coagulase-negative Staphylococci (CNS), identified
at the Microbiology Laboratory - UNIFESP.
Design: Experimental laboratory investigation.
Methods: The Minimum Inhibitory Concentrations
of 21 strains of methicillin-resistent coagulase-negative Slaphylococcus
and 22 methicillin-sensitive coagulase-negative Staphylococcus
were determined to ciprofloxacin, ofloxacin, gatifloxacin and moxifloxacin,
using E-test method standardized by the National Committee for Clinical
Laboratory Standards (NCCLS).
| Results:
The MICs90 (ug/ml) for 43 CNS Isolates to ciprofloxacin, ofloxacin,
gatifloxacin and moxifloxacin were: |
| |
Total
Strain |
MIC90Cipro |
MIC90
Oflox |
MIC90
Gati |
MIC90
Moxi |
| MR SCN |
21 |
32 |
32 |
2.0 |
3.0 |
| MS SCN |
22 |
0.25 |
1.0 |
0.125 |
0.125 |
| SCN |
43 |
|
|
|
|
MR SCN = methicillin-resistent
coagulase-negative Staphylococcus; MS SCN = methicillin-sensitive
coagulase-negative Staphylococcus; SCN = coagulase-negative
Staphylococcus.
Conclusion: Our results indicated that methicillin-sensitive
CNS were more susceptible to quinolones than methicillin resistant
CNS and that fourth generation fluorquinolones appear to be more
potent covering bacterial resistance to second generation for the
coagulase-negative Staphylococcal strains.
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