The Charles T. Campbell Eye Microbiology Lab
UPMC | University of Pittsburgh Medical CenterUniversity of Pittsburgh Schools of the Health Sciences
HomeAbout UsLab Diagnostic TestingAntibiotic SusceptibilityAntimicrobial TherapyCurrent ResearchContact Us


2004 OMIG, Abstract 14

OMIG Main Page | 2004 Abstracts | < Previous | Next >

In vitro Susceptibilities of Ocular Isolates Coagulase-Negative Staphylococci to Fluoroquinolones in Sao Paulo, Brazil
A Oliveira, AL Hofling-Lima, R Belfort, MF Gayoso. Universidade Federal de Sao Paulo, Departmento de Oftalmologia, Sao Paolo, Brazil

Purpose: To evaluate the fluoroquinolone susceptibilities of forty three ocular isolates coagulase-negative Staphylococci (CNS), identified at the Microbiology Laboratory - UNIFESP.
Design: Experimental laboratory investigation.
Methods: The Minimum Inhibitory Concentrations of 21 strains of methicillin-resistent coagulase-negative Slaphylococcus and 22 methicillin-sensitive coagulase-negative Staphylococcus were determined to ciprofloxacin, ofloxacin, gatifloxacin and moxifloxacin, using E-test method standardized by the National Committee for Clinical Laboratory Standards (NCCLS).

Results: The MICs90 (ug/ml) for 43 CNS Isolates to ciprofloxacin, ofloxacin, gatifloxacin and moxifloxacin were:
  Total Strain MIC90Cipro MIC90 Oflox MIC90 Gati MIC90 Moxi
MR SCN 21 32 32 2.0 3.0
MS SCN 22 0.25 1.0 0.125 0.125
SCN 43        

 

 




MR SCN = methicillin-resistent coagulase-negative Staphylococcus; MS SCN = methicillin-sensitive coagulase-negative Staphylococcus; SCN = coagulase-negative Staphylococcus.

Conclusion: Our results indicated that methicillin-sensitive CNS were more susceptible to quinolones than methicillin resistant CNS and that fourth generation fluorquinolones appear to be more potent covering bacterial resistance to second generation for the coagulase-negative Staphylococcal strains.

OMIG Main Page | 2004 Abstracts | < Previous | Next >

Top of Page


Web Site Terms of Use | E-mail Terms of Use | Medical Advice Disclaimer
UPMC | Affiliated with the University of Pittsburgh Schools of the Health Sciences | Contact UPMC