Ocular Microbiology and Immunology Group
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2004 Abstracts and Meeting Agenda

38th Annual Meeting
Hotel Monteleone
New Orleans, Louisiana
October 23, 2004

MODERATOR:James Chodosh, M.D.

7:00 a.m. Abstract 1: A Novel Topical Antiviral Agent, PCL-016 (Picolinic Acid), Inhibits Adenovirus Replication in the Ad5/NZW Rabbit Ocular Model
EG Romanowski, KA Yates, RP Kowalski, FS Mah, YJ Gordon. The Charles T. Campbell Laboratory, University of Pittsburgh, Pittsburgh, PA

7:08 a.m. Abstract 2: An Animal Model of Mycobacteria Infection Under Corneal Flaps for Refractive Surgery
CBD Adan, EH Sato, LB Sousa RS Oliverira, SC Leao, D Freitas. Departments of Ophthalmology and Department of Microbiology, Immunology, and Parasitology, Federal University of Sao Paulo, Brazil

7:16 a.m. Abstract 3: Eliminating Trachoma: Fly Control or Antibiotics?
S Lee¹, A Wondu², M Muluken², D Lee¹, E Yi¹, Z Zhou¹, V Cevallos¹, K Donnallan¹, J Chidambaram¹, B Gaynor¹, J Whitcher¹, T Lietman¹. ¹UCSF Department of Ophthalmology, Proctor Foundation and ²Orbis International, Ethiopia

7:24 a.m. Abstract 4: Passive Immunization Therapy for Experimental Staphylococcal Keratitis
AR Caballero, JT Bush, JJ Dajcs, ME Marquart, BA Thibodeaux, RJ O'Callaghan. LSU Health Sciences Center, Department of Microbiology, New Orleans, Louisiana

7:32 a.m. Abstract 5: LasA Protease as a Therapeutic Agent in Staphylococcal Keratitis
IS Barequet¹, Y Pessach², GJ Ben Simon¹, M Safrin¹, M Rosner¹, E Kessler^1
1Goldschleger Eye Institute, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Hashomer, Israel and ²Department of Ophthalmology, SZMC, Jerusalem, Ben Gurion University of the Negev, Israel

7:40 a.m. Abstract 6: Corneal Virulence of Non-Capsular Streptococcus pneumoniae
ME Marquart, JM Reed, RJ O'Callaghan, DO Girgis, CC McCormick, AR Caballero. Department of Microbiology, Immunology, and Parasitology, Louisiana State University, New Orleans, Louisiana

7:48 a.m. Abstract 7: Combination of Pharamacokinetics and Susceptibility Data as Predictive Indicator of Bacterial Keratitis
DW Stroman¹, JJ Dajcs¹, R Vidal², Mridvika², C Martinez², BA Thibodeaux³, RJ O'Callaghan³, BA Schlech¹. ¹Alcon Research, Ltd, Fort Worth, Texas, ²Icon Cusi, Barcelona, Spain, ³LSU Health Sciences Center, New Orleans, Louisiana

7:56 a.m. Abstract 8: Is Zymar^TM (gatifloxacin 0.3%) Better Than Ciloxan^TM or Fortified Tobramycin in the Treatment of Experimental Gram-Negative Keratitis?
FS Mah, RP Kowalski, EG Romanowski, KA Yates, BR Kowalski, YJ Gordon. The Charles T. Campbell Laboratory, University of Pittsburgh, Pittsburgh, PA

8:04 a.m. Abstract 9: Comparison of In-Vitro Sensitivity Rates of the Ophthalmic Fluoroquinolones and Vancomycin Against Propionibacterium acnes Ocular Isolates
M Shah, D Ritterband, TL Kajura, W Perez, D Shapiro, JA Seedor, R Koplin
New York Eye and Ear Infirmary Department of Ophthalmology, New York, New York

8:12 a.m. Abstract 10: Clinical Diagnosis, Isolate Frequency, and Susceptibility Profiles for Community Patients Pretreated with 4th Generation Fluoroquinolones
D Miller, E Alfonso, M Diaz, E Perez. Bascom Palmer Eye Institute, Miami, Florida

8:20 a.m. Abstract 11: Comparison of In-Vitro Resistant Rates of Daptomycin and the Ophthalmic Fluoroquinolones Against Methicillin Resistant Staphylococcus aureus (MRSA) Ocular Isolates
S Meskin, TL Kaiura, M Shah, D Ritterband, D Shapiro, J Seedor. New York Eye and Ear Infirmary Department of Ophthalmology, New York, New York

8:28 a.m. Abstract 12: Non-Invasive Fluorophotometry Assessment of Corneal Epithelial Permeability After Exposure to Vigamox^TM or Zymar^TM
BE McCarey, HF Edelhauser. Emory Eye Center, Atlanta, Georgia

8:36 a.m. Abstract 13: Assessment of Corneal Toxicity Following Exposure to VigamoxD or ZymarD Using in vivo Confocal Microscopy and ZO-1 Staining
W M Petroll, HD Cavanagh, JV Jester. Department of Ophthalmology, University of Texas Southwestern, Dallas, Texas

8:44 a.m. Abstract 14: In vitro Susceptibilities of Ocular Isolates Coagulase-Negative Staphylococci to Fluoroquinolones in Sao Paulo, Brazil
A Oliveira, AL Hofling-Lima, R Belfort, MF Gayoso. Universidade Federal de Sao Paulo, Departmento de Oftalmologia, Sao Paolo, Brazil

8:52 a.m. Abstract 15: Biofilm Formation by E.faecalis on Intraocular Lens Material
S Kobayakawa¹, M Gilmore². ¹Department of Microbiology and Immunology, U. Of Oklahoma, Oklahoma City, Oklahoma ²Department of Ophthalmology, U. Of Oklahoma, Oklahoma City, Oklahoma

9:00 a.m. Abstract 16: A Study of the Effectiveness of Preoperative Antibiotics on the Incidence of Postoperative Endophthalmitis in a Clinical Setting
GM Bohigian. Department of Ophthalmology, Washington University, St Louis, Missouri

9:08 a.m. Abstract 17: Intravitreal Vigamox^TM (0.5% Moxifloxacin) is Non-Toxic and Effective in Preventing Endophthalmitis in a NZW Rabbit Model
RP Kowalski, EG Romanowski, FS Mah, KA Yates, YJ Gordon. The Charles T. Campbell Laboratory, University of Pittsburgh, Pittsburgh, PA

9:16 a.m. Abstract 18: Influence of Vancomycin on Adhesion of a Staphylococcus epidermidis Strain Encoding ica Locus to Intraocular Lenses
L Kodjikian^1,2,3,4, S Baillif^1,2, C Roques⁶, J Garweg⁴, J Freney^3,5, C Burillon^2,3.
¹Department of Ophthalmology, Croix-Rousse Hospital, Lyon, France ²Department of Ophthalmology, Edouard Herriot Hospital, Lyon, France ³Laboratory "Biomaterials and Matrix Remodeling", EA 3090, Claude Bernard University Lyon, France ⁴Department of Ophthalmology, Inselspital, Bern University, Bern, Switzerland ⁵Department of Microbiology, Institute of Pharmaceutical and Biological Sciences, Lyon, France ⁶Department of Microbiology, EA 819, Xenobiotics Kenetics, Pharmacy Faculty, Paul Sabatier University, Toulouse, France

9:24 a.m. Abstract 19: Comparison of the Penetration into Aqueous Humor in Humans of Two 4th Generation Fluoroquinolones
JP McCulley, W Shine. University of Texas Southwestern Medical School, Dallas, Texas

9:32 a.m. Abstract 20: Efficacy of Intrastromal Corneal Injection of Natamycin on Experimental Fusarium solani Keratitis in Rabbits
L Barbosa de Sousa, AI Shiguematsu, AS Schellini, OF Gompertz, E Bagagli, CA Padovani. Department of Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil

9:40 a.m. Thygeson Lecture - Pseudomonas aeruginosa: Models and Treatment of the Disease
Linda D. Hazlett, Ph.D.

10:02 a.m. Closing Comments and Awards

10:05 a.m. Adjourn

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