Ocular Microbiology and Immunology Group
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2012 OMIG Abstract 13

Evaluation of Surgical Margins During Treatment of Ocular Surface
Squamous Neoplasia
P. Chan, S. Pabon, L. Schoenfield, A. Sing
Cleveland Clinic, Cole Eye Institute, Cleveland, OH

Purpose: To evaluate the role of surgical margins in management of ocular surface squamous neoplasms (OSSN).

Methods: A retrospective case series analysis of patients presenting with ocular surface lesions requiring surgical excision was conducted. Cases treated surgically were included for analysis. All lesions were excised with 1-2mm margins and treated with double freeze-thaw cryotherapy by a single surgeon (AS). Conjunctival defects were all closed primarily.
 
Results: Of the 58 eyes identified in the cohort from 2004 to 2012, 30 eyes met criteria for inclusion. Mean follow-up time was 24.4 months (range: 1-84 months). Seventeen of the lesions had corneal involvement. Mean initial best-corrected visual acuity (BCVA) was logMar 0.29, compared to a postoperative BCVA of 0.26 (p=0.099). Pathological distribution of the lesions included 24 pre-invasive OSSN and 6 invasive OSSN. Of the pre-invasive eyes, 3, 9, and 12 had mild, moderate, and severe dysplasia, respectively. Eight of the lesions had positive pathological margins. At one year, 15 of 17 (88%) of the patients did not have clinical evidence of recurrence. 

Conclusion: OSSN can be managed surgically using smaller margins without compromise of clinical outcomes. This may improve anatomical results and minimize the morbidity of the treatment. 

Disclosure: N

2012 Agenda and Abstracts | < Previous | Next >