The Charles T. Campbell Eye Microbiology Lab
UPMCUniversity of Pittsburgh Schools of the Health Sciences
HomeContact InformationLab Diagnostic TestingAntibiotic SusceptibilityAntimicrobial TherapyCurrent ResearchPhotos


Ocular Microbiology and Immunology Group
Back to OMIG Main Page

2013 Agenda and Abstracts | < Previous | Next >

2013 OMIG Abstract 2

Corneal and Intraocular Invasion of Ocular Surface Squamous Neoplasia After Intraocular Surgery
Juan C. Murillo, MD1, Anat Galor, MD1, Michael C. Wu, MD2, Natasha K. Kim, MD2, Carol L. Karp, MD1
1Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
2University of Washington School of Medicine, Seattle, WA

Purpose: To describe two unusual cases of ocular surface squamous neoplasia (OSSN) of the conjunctiva with corneal and intraocular extension following intraocular surgery.

Methods: In this clinicopathologic small case series, two cases of OSSN managed at two tertiary ocular institutions are described. Clinical features, pathologic characteristics and relevant imaging are described.

Results: OSSN is considered to be a low-grade malignancy and its behavior is not typically aggressive, unless the patient is immunocompromised. Intraocular invasion is not common. Ocular surgery seems to facilitate intraocular extension of OSSN, with the theory that neoplastic cells may gain entry to the eye via a penetrating incision. In both of our cases, invasion of the OSSN was described following an intraocular surgical procedure: cataract surgery and penetrating keratoplasty (PK). Both patients had a history of a previous OSSN excision at the corneoscleral limbus. Case one presented 36 months after cataract surgery with progressive decrease in visual acuity and significant corneal scarring originating from the surgical site. Penetrating keratoplasty was performed. Histopathology reported midstromal infiltrative carcinoma. Case two
had a history of herpes simplex keratitis and underwent a repeat PK for a perforated ulcer. Four months post-operatively there was low-grade inflammation, recalcitrant to corticosteroid and antiviral therapy. Cytology of the anterior chamber aspirate revealed squamous cells. Argon laser demonstrated epithelial ingrowth, which upon ultimate surgical excision was confirmed as neoplastic ingrowth.

Conclusion: Patients with a history of OSSN may be at increased risk of neoplastic intraocular extension following intraocular surgery.

Disclosure: N

2013 Agenda and Abstracts | < Previous | Next >

 

 

space