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OMIG Main Page | 2002 Abstracts | < Previous | Next> The
In Vitro Susceptibility of Bacterial Endophthalmitis Isolates to
Azithromycin Purpose: Oral azithromycin has demonstrated an extended elimination half-life and is reported to have good ocular tissue penetration. Oral azithromycin may be efficacious in the initial management of 'high risk' patients presenting with penetrating trauma associated with organic matter contamination. This in vitro study tests the susceptibilities of 93 bacterial endophthalmitis isolates against azithromycin. Methods: The MICs (mcg/ml) of 93 bacterial endophthalmitis isolates were determined to azithromycin using E-tests. The median MIC values were calculated for each bacterial species. Susceptibility to azithromycin was defined as an MIC value #2 mcg/ml, based on the National Committee of Clinical Lab Standards (NCCLS). Results: Median MICs (mcg/ml) and susceptibility of 93 bacterial endophthalmitis isolates to azithromycin.
Conclusion:
Our In vitro study suggests that azithromycin is effective against
Bacillus sp. (88.9% susceptible), Streptococcus pneumoniae (90%),
and beta-hemolytic strep (100%). However, azithromycin does not
show acceptable activity against S. aureus (except for FQS-MS isolates);
Coagulase-negative Staph (except FQS-MS isolates), Strep viridans
group, Gram negative rods, Haemophilus sp.and Enterococcus. In vivo
studies are required to evaluate the effectiveness of oral azithromycin
against infectious endophthalmitis. OMIG Main Page | 2002 Abstracts | < Previous | Next>
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