2002 Ocular Microbiology and Immunology Group, Abstract 12

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Will the new generation of fluoroquinolone antibiotics become the antimicrobials of choice in endophthalmitis prophylaxis?
M. Shah, D. Ritterband, A. Dingley, R. Koplin, J. Seedor. The New York Eye and Ear Infirmary, New York, NY.

Purpose: To compare the in vitro susceptibility profiles of gentamicin (GEN), ciprofloxacin(CIP), ofloxacin(OFX), gatifloxacin(GAT), moxifloxacin(MOX) and vancomycin (VAN) against microorganisms responsible for endophthalmitis following cataract and glaucoma filtering surgery.

Methods: The MIC's of 43 post-cataract endophthalmitis isolates and 37 bleb-related endophthalmitis isolates cultured between January 1, 1994 and June 30, 2000 were tabulated using E-test strips.

Results: The order of significant susceptibility for Staphylococcus epidermidis and Staphylococcus aureus post-cataract endophthalmitis isolates (37of 43 isolates) were
VAN>MOX=GAT>GENT>CIP=OFX. The order of significant susceptibility for Staphylococcus epidermidis and Staphylococcus aureus bleb-related endophthalmitis isolates (23 of 37 isolates) were VAN>MOX=GAT>CIP=OFX>GENT. All post-cataract and bleb endophthalmitis Streptococcus isolates were 100% susceptible to VAN. The order of significant susceptibility of Streptococcus isolates was MOX=GAT>CIP=OFX.

Conclusion: Our in vitro study suggests that the newer generation of fluoroquinolone antibiotics (MOX and GAT) are more potent than the commercially available agents (CIP, GENT, OFX) against Staphylococcus species causing endophthalmitis. The data agrees with previous in vitro data from our archived Staphylococcus species.

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